What is the Pelger Hu ë t anomaly of 
and
dogs? What are its characteristics? Is it possible to diagnose and treat this abnormality?
and
are only found in very few cases, but the abnormality of Pelger Hu ë t (APH) has a devastating impact on the litter size of affected puppies. They usually die in the fetus or quickly after delivery. Severe deformities occur in dogs with abnormal survival of Pelger Hu ë t. Let’s look at this disease in more detail.
is a rare and fatal genetic disease.
Pelger Hu ë t anomaly is a rare genetic disease, which is fatal to most affected puppies. It is associated with lack or inadequate mitosis and affects neutrophils. These cells belong to the leukocyte line and play a central role in the immune system.
neutrophils are blood cells, more accurately, non-specific leukocytes, that is, they do not target a single antigen. Under normal conditions, the nucleus of neutrophils is composed of chromatin (a substance mainly composed of DNA and protein), which is composed of several aggregates of this substance to form particles visible under the microscope. In the case of Pelger Hu ë t abnormality, these granulocytes are marked by mature chromatin aggregation: particle aggregation disappears. The loss of this structure will affect the function of neutrophils, resulting in severe immune deficiency.
and
are homozygous, in other words, in dogs carrying two copies of the responsible gene, The abnormality of Pelger Hu ë t can lead to serious morphological changes and death, usually in the womb or shortly after the birth of the puppy. The chances of survival are really low.
in puppies carrying only one heterozygous form of the APH gene, These puppies have no symptoms and are considered completely feasible. However, it is not recommended to use them for breeding or only with individuals carrying two healthy copies of the HPA gene.
there are also Pelger Hu ë t abnormalities in humans.
Which varieties are prone to Pelger Hu ë t anomaly? Many aspects of the
Pelger Hu ë t anomaly are unclear. This includes the mode of transmission of the disease, which may be genetic.
in addition, most PHA cases occur in Australian shepherds. German shepherds, border shepherds, English cocks and Samoyed dogs are also considered to be one of the dog breeds that may exhibit perger Hutt abnormalities, although they are much weaker than Australian shepherds, bassengi dogs and black fire dogs hunting raccoons Can PHA be prevented or treated?
is very difficult to prevent Pelger Hu ë t abnormality, because its diagnosis is the same. In fact, the fact that it is difficult to diagnose hinders the identification of affected animals, thus hindering the study of this disease. So far, the genes related to APH have not been identified. There is no treatment.
in addition, symptoms may cause confusion because they may be regarded as signs of early infection or even leukemia. Pelger-h abnormality screening testThis is done by blood smears, but similarly, a negative result of blood smears does not necessarily mean that the dog is not affected. Therefore, the main preventive measure is to avoid breeding a dog officially recognized as a perger Hutt anomaly carrier. One indicator of this is that it produces pups of different sizes, some of which are characterized by a large number of stillbirths. Because genes are brewed in the breeding process: the affected puppies will be those who receive two copies of the mutant gene.
breeders of dogs from risk breeds are required to test and take into account their dog’s breeding history.
